| November | 2009 | Authorized by UT System Board of Regents to begin planning effort |
| December | 2009 | Launched internal planning process of Executive Committee, Steering Committee and 12 Planning Groups comprised of physicians, nurses, institutional leaders, and community supporters |
| August | 2010 | Submission of comprehensive plan to Board of Regents for construction approval |
| August | 2010 | Construction of new hospital approved by Texas Higher Education Coordinating Board |
| April | 2011 | Construction of new hospital begins |
| April | 2012 | UT Southwestern announces new university hospital will be named to honor former Gov. William P. Clements Jr. |
| Late | 2014 | The new William P. Clements Jr. University Hospital opens |

