Biography

  • 2018-Present: Assistant Professor; UT Southwestern Medical Center
  • 2017-2018: Senior Scientist; Icahn School of Medicine at Mount Sinai
  • 2013-2017: Postdoc Fellow; Icahn School of Medicine at Mount Sinai

Research Interest
  • Liver cancer and liver cirrhosis
  • Long read-based alternative splicing detection
  • Pacbio SMRTseq-based DNA methylation detection
  • Single cell sequencing

Publications

Featured Publications LegendFeatured Publications

Neuronal impact of patient-specific aberrant NRXN1a splicing.
Flaherty E, Zhu S, Barretto N, Cheng E, Deans PJM, Fernando MB, Schrode N, Francoeur N, Antoine A, Alganem K, Halpern M, Deikus G, Shah H, Fitzgerald M, Ladran I, Gochman P, Rapoport J, Tsankova NM, McCullumsmith R, Hoffman GE, Sebra R, Fang G, Brennand KJ, Nat. Genet. 2019 Dec 51 12 1679-1690
MatrixEpistasis: ultrafast, exhaustive epistasis scan for quantitative traits with covariate adjustment.
Zhu S, Fang G Bioinformatics 2018 Jul 34 14 2341-2348
GIGSEA: Genotype Imputed Gene Set Enrichment Analysis using GWAS Summary Level Data.
Zhu S, Qian T, Hoshida Y, Shen Y, Yu J, Hao K Bioinformatics 2018 Jul
Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing.
Zhu S, Beaulaurier J, Deikus G, Wu TP, Strahl M, Hao Z, Luo G, Gregory JA, Chess A, He C, Xiao A, Sebra R, Schadt EE, Fang G Genome Res. 2018 07 28 7 1067-1078
Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation.
Beaulaurier J, Zhu S, Deikus G, Mogno I, Zhang XS, Davis-Richardson A, Canepa R, Triplett EW, Faith JJ, Sebra R, Schadt EE, Fang G, Nat. Biotechnol. 2018 01 36 1 61-69
Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells.
Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Readhead B, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ Cell Rep 2016 05 15 5 1024-1036
Molecular heterogeneity in hepatocellular carcinoma.
Zhu S, Hoshida Y Hepat Oncol 2018 Jan 5 1 HEP10
DNA methylation on N(6)-adenine in mammalian embryonic stem cells.
Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD, Mackintosh SG, Zhong M, Tackett A, Wang G, Hon LS, Fang G, Swenberg JA, Xiao AZ Nature 2016 Mar
Hidden Markov induced Dynamic Bayesian Network for recovering time evolving gene regulatory networks.
Zhu S, Wang Y, Sci Rep 2015 Dec 5 17841
A Cytosine Methyltransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen [corrected].
Chao MC, Zhu S, Kimura S, Davis BM, Schadt EE, Fang G, Waldor MK, PLoS Genet. 2015 Nov 11 11 e1005666